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Abstract
Chronic EEG data analysis in male epileptic rats revealed interictal epileptiform activity rhythms with periodicity of about 2-3 and 5-7 days.
- Epilepsy may exhibit cyclical patterns in brain activity across different time scales, including circadian and multidien rhythms.
- Seizures appear to cluster at specific phases of these underlying rhythms, indicating critical times of increased seizure risk.
- Multidien rhythms observed were not synchronized among different rats or with human interventions, suggesting an internal timing mechanism.
- Factors influencing the timing of seizures across species remain unknown but are associated with these cyclical patterns.
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