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The Importance of Endogenously Secreted GLP-1 and GIP for Postprandial Glucose Tolerance and β-Cell Function After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy Surgery
The role of natural GLP-1 and GIP hormones in blood sugar control and insulin cell function after gastric bypass and sleeve gastrectomy surgery
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Abstract
Postprandial GLP-1 concentrations were highest after Roux-en-Y gastric bypass (RYGB) compared to other groups.
- Postprandial GLP-1 levels were elevated after sleeve gastrectomy (SG) relative to unoperated individuals.
- Postprandial GIP levels were lowest following RYGB.
- GLP-1 receptor blockade decreased β-cell glucose sensitivity and increased postprandial glucose responses in SG and RYGB groups but had no effect in unoperated individuals.
- GIP receptor blockade reduced β-cell glucose sensitivity and increased postprandial glucose responses in unoperated and SG individuals, but not in those who underwent RYGB.
- The findings suggest GIP is the primary incretin hormone in unoperated individuals, while GLP-1 and GIP play equal roles after SG, and GLP-1 is predominant after RYGB.
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