Cell communication and signaling : CCSNov 1, 2026

The role of blood vessel lining's internal clock in controlling repair and narrowing after injury

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Nov 3, 2026

Abstract

Disruption of circadian signaling is linked to exaggerated and delayed endothelial repair.

Circadian rhythms influence cardiovascular physiology and disease.
is a key component of the molecular clock that helps maintain vascular health.
The role of endothelial cell-derived Bmal1 in post-injury neointimal hyperplasia is not well understood.
Understanding EC-derived Bmal1 may clarify mechanisms involved in vascular restenosis.

Simplified

Circadian rhythms have been implicated in the regulation of cardiovascular physiology and disease. Disruption of circadian signaling has been linked to exaggerated and delayed endothelial repair. , a core component of the molecular clock, plays a critical role in maintaining vascular homeostasis. However, the specific contribution of endothelial cell (EC)-derived Bmal1 to post-injury neointimal hyperplasia remains unclear. This study aims to elucidate the role and mechanisms of EC-derived Bmal1 in vascular restenosis.

Key numbers

n=12 for Tie2-KO

Increase in Neointimal Area

Neointimal area in carotid artery ligation model

2.6×

Endothelial Cell Proliferation

ICAM-1 expression increase in -deficient HUVECs

n=6 per group

VSMC Proliferation

Cell migration measured by wound healing in RVSMCs

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The role of blood vessel lining's internal clock in controlling repair and narrowing after injury

Abstract

Key numbers

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