Enhancing female fertility by biomaterial-based regeneration of uterine tubes

Dec 1, 2025Cell transplantation

Improving female fertility by using biomaterials to repair fallopian tubes

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Regenerative Health on OpenScience ↗PubMed ↗DOI ↗OA ↗

Abstract

A review of 42 studies indicates that biomaterials and organoid systems may enable the regeneration of uterine tubes, which are crucial for natural conception.

Natural polymers like collagen and decellularized extracellular matrix can create biocompatible scaffolds that mimic the body's own environment.
Synthetic polymers allow for control over mechanical properties and reproducibility in tissue engineering applications.
Hydrogels create a 3D environment that supports important biological processes such as cell differentiation and embryo development.
Uterine tube-derived organoids can serve as relevant models for understanding diseases and testing drugs.
Advancements in 3D and magnetic bioprinting have led to artificial uterine tube models that closely resemble natural tissue structure.

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Tubal factor infertility remains a major cause of female reproductive dysfunction. Current therapeutic options, such as surgical repair orfertilization, only bypass but do not restore the dysfunctional uterine tube. Recent advances in (TERM) highlight biomaterials and organoid systems as promising tools to regenerate oviductal tissue and thus support natural conception. The manuscript comprehensively reviews 42 studies focused solely on TERM of the uterine tubes. Current status of uterine tube tissue engineering demonstrates that natural polymers, including collagen and decellularized extracellular matrix, provide biocompatible scaffolds capable of mimicking native extracellular environments. Synthetic polymers enable adjustment of mechanical properties and reproducibility, while hydrogels offer a biomimetic 3D microenvironment that supports epithelial differentiation, angiogenesis, and embryo development. Moreover, uterine tube-derived organoids, in which the polymeric component plays a crucial role, provide physiologically relevantmodels for studying pathology, drug testing, and translational applications. Recent advances in 3D bioprinting and magnetic bioprinting have enabled the development of artificial uterine tube models that better mimic native tissue architecture and cell organization. These findings underscore the translational potential of biomaterial-based strategies for uterine tube regeneration. Their integration into reproductive medicine may offer novel therapeutic avenues for restoring tubal function, improving fertility outcomes, and advancing patient-specific approaches in the management of female infertility. in vitro in vitro

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Enhancing female fertility by biomaterial-based regeneration of uterine tubes

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