Mechanisms of ageing and developmentJul 28, 2026

Improving the Anti-Aging Effects of Human Umbilical Cord Stem Cells with NMN in Aging Mouse and Cell Models

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗

Updated Aug 3, 2026

Abstract

Combined treatment with human umbilical cord-derived mesenchymal stem cells and nicotinamide mononucleotide significantly improved anti-aging effects in mice.

The combination therapy resulted in marked alleviation of thymic and splenic atrophy.
Body weight loss was attenuated in mice receiving the combined treatment.
Motor and cognitive functions significantly improved in D-galactose-induced aging mice with the combined therapy.
In vitro findings showed reduced cellular aging in lymphocytes and decreased oxidative stress in stem cells with combined treatment.
Activation of the Nrf2/HO-1 pathway by nicotinamide mononucleotide helped maintain the stem cells' anti-aging properties.

Simplified

Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have emerged as a promising therapeutic option for anti-aging therapy. However, the aging microenvironment can induce oxidative stress and senescence in transplanted hUC-MSCs, thereby impairing their capacity to delay immunosenescence. Combining MSC-based therapy with antioxidants may enhance therapeutic efficacy. This study explored whether hUC-MSCs could exert enhanced anti-immunosenescence effects when administered in combination with nicotinamide mononucleotide (NMN). Compared with either treatment alone, the combined administration exerted enhanced anti-aging efficacy, as evidenced by marked alleviation of thymic and splenic atrophy, attenuation of body weight loss, and significant improvement in motor and cognitive functions in D-galactose-induced aging mice. In vitro results indicated that combined treatment with hUC-MSCs and NMN alleviated cellular senescence in lymphocytes while simultaneously reducing oxidative stress and senescence in hUC-MSCs. Mechanistically, activation of the Nrf2/HO-1 pathway by NMN mitigated hUC-MSC senescence under stress conditions, thereby preserving their anti-aging properties. Taken together, our study provides a promising combinatorial approach that sustains stem cell function and amplifies anti-aging efficacy.

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Improving the Anti-Aging Effects of Human Umbilical Cord Stem Cells with NMN in Aging Mouse and Cell Models

Abstract

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