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Enzyme-Catalyzed One-Step Synthesis of Ionizable Cationic Lipids for Lipid Nanoparticle-Based mRNA COVID-19 Vaccines
Enzyme-made charged fats for lipid nanoparticles in mRNA COVID-19 vaccines
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Abstract
The AA3-DLin lipid nanoparticles (LNPs) demonstrated outstanding mRNA delivery efficacy and long-term storage capability.
- Ionizable cationic lipid-containing LNPs are advanced non-viral gene delivery platforms with potential in gene therapeutics.
- The AA3-DLin LNPs encapsulating SARS-CoV-2 spike mRNAs induced strong immunogenicity in a BALB/c mouse model.
- Immunogenicity was assessed through antibody titers, virus challenge, and T cell immune response studies.
- A chemical library of ionizable cationic lipids was developed using a one-step enzyme-catalyzed esterification method.
- The study provides insights into lipid design, synthesis, screening, optimization, fabrication, characterization, and application.
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