Green Tea Compound May Slow Blood Vessel Aging and Cell Aging by Changing Cell Recycling and Iron-Related Cell Death through the Sirtuin 1 Pathway

EGCG reduced experimental vascular aging markers by activating SIRT1-linked autophagy and suppressing ferroptosis.

Preclinical in vitro endothelial-cell senescence experiments and in vivo mouse studies reported less senescence signaling, lower aortic SA-beta-gal staining, and reduced pulse wave velocity in the EGCG group compared with controls.

The evidence comes from doxorubicin-induced cell senescence and mouse models, with no human vascular aging outcomes reported.