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Epigallocatechin-3-gallate inhibit replication of white spot syndrome virus in Scylla paramamosain
Epigallocatechin-3-gallate reduces replication of white spot virus in mud crabs
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Abstract
Treatment with 1 mg/kg EGCG significantly increased the resistance of mud crabs to white spot syndrome virus (WSSV) compared with the control.
- EGCG treatment at 1 mg/kg may enhance the survival rate of crabs challenged with WSSV.
- A higher dose of 1.5 mg/kg EGCG killed crab hemocytes, indicating a potential toxicity at elevated levels.
- EGCG treatment is associated with the induction of immune pathways, such as the phenoloxidase and JAK-STAT pathways.
- EGCG + WSSV treatment significantly reduced the number of WSSV copies in crabs at 24, 48, and 72 hours post-challenge.
- EGCG may improve innate immunity and inhibit WSSV replication by blocking the expression of late-stage WSSV genes.
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