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Dissecting epigenetic age acceleration in amyotrophic lateral sclerosis
Understanding faster biological aging in amyotrophic lateral sclerosis
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Abstract
In a study of 5,146 ALS patients and 2,156 healthy controls, altered white blood cell proportions were found to confound biological aging assessments.
- No significant difference in biological aging pace was observed between ALS patients and controls, except in those with a specific genetic mutation.
- The increase in biological aging previously noted in ALS patients may be influenced by variations in white blood cell types.
- After adjusting for cell counts, accelerated epigenetic aging was not evident in the majority of ALS patients compared to controls.
- scores did not correlate with survival outcomes in ALS patients.
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Key numbers
0.915
Correlation with Zhang Clock
Among 6,048 individuals with known chronological ages
5,022
Survival analysis cohort size
Subset of ALS individuals with known survival time and status
N
Patients with C9orf72 repeat expansion
Comparison of aging metrics in ALS patients