Accelerating epigenetic age in right-sided colon cancer predicts a favorable outcome

Dec 30, 2025Clinical epigenetics

Faster biological aging in right-sided colon cancer is linked to better outcomes

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Abstract

Colorectal cancer patients with right-sided tumors may have a significantly older epigenetic age than those with left-sided tumors.

Right-sided colon cancer (RCC) has an older epigenetic age compared to left-sided colon cancer (LCC).
EAA is greater in female and microsatellite instability-high RCC samples compared to LCC.
Epigenetic age decreases from RCC stage I to IV, while LCC shows the greatest decrease in stage I.
EAA may be negatively associated with mortality in RCC and positively associated in LCC.
These findings suggest EAA could help understand the biological aging aspect of colorectal cancer.

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BACKGROUND: DNA methylation age, referred to as 'epigenetic age, epiAge' is an accurate biomarker for aging, including cancer. As a well established age-associated disease, colorectal cancer (CRC) is a highly heterogeneous cancer and can be divided into left-sided colon cancer (LCC), right-sided colon cancer (RCC) and rectal cancer according to the anatomical location of the tumor. However, the association of epigenetic age acceleration (EAA) with CRC tumor location, clinical characteristics, and patient outcomes remain to be clarified.

METHODS: A total of 548 samples were collected for epiAge estimation, including 192 samples consisting of 96 CRC tumors and 96 matched normal tissues from GSE77718 and 356 CRC tumors from The Cancer Genome Atlas (TCGA). EpiAge were computed using four different epiAge models (Horvath2013, PhenoAge, ZhangQ2019, and EpiTOC). EpiAge and EAA were compared between LCC and RCC. Log rank test was used to assess the association of EAA with LCC and RCC survival.

RESULTS: A significantly older epiAge in the RCC than LCC was observed (P = 0.00025) but not in normal colon tissues. In addition, compared with LCC, EAA was enhanced in female and microsatellite instability-high RCC samples. Meanwhile, we found that epiAge decreased continuously from RCC stage I to stage IV. In contrast, in LCC, stage I had the most serious epiAge deceleration (stage I: - 8.9; stage II: - 1.71; stage III: - 4.91; stage IV: - 4.67). Further, EAA is significantly and negatively or positively associated with RCC and LCC mortality, respectively.

CONCLUSIONS: Overall, our results suggest that EAA may be a useful biomarker for gaining a deeper understanding of CRC high heterogeneity from a biological aging perspective and will facilitate prognostic judgement and targeted treatments.

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Accelerating epigenetic age in right-sided colon cancer predicts a favorable outcome

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