WTC exposure is associated with an of 3.789 years.
Epigenetic aging is estimated using various clocks, including Hannum, Horvath, and PhenoAge.
After adjustments, WTC exposure showed a significant association with accelerated aging as measured by the Hannum clock.
Similar associations were observed with the Horvath and PhenoAge clocks, but not with GrimAge.
Cancer diagnosis in participants was linked to accelerated aging, with a β of 1.658.
The findings indicate that WTC exposure may accelerate biological aging, regardless of breast cancer status.
AI simplified
Aging is a complex biological process, and some individuals are aging faster or slower than expected. This phenomenon of aging acceleration occurs when biological age exceeds chronological age and can be assessed by epigenetic clock estimation. As aging acceleration is known to occur in response to some environmental exposures as well as trauma, we hypothesized that World Trade Center (WTC) exposures may have led to . WTC-exposed women were selected from the World Trade Center Environmental Health Center (WTC EHC) clinic, with peripheral blood collected during routine clinical monitoring visits. The reference group was selected from the NYU Women's Health Study (NYUWHS), a prospective cohort study that collected blood samples before 9/11/2001. Epigenomes of WTC-exposed vs. unexposed women were profiled using the Infinium MethylationEPIC array. DNA-based epigenetic aging was estimated using Hannum, Horvath, PhenoAge and GrimAge epigenetic clocks. Age acceleration was defined as the residual from regressing estimated epigenetic age on chronological age. Ordinary least squares regression was used to investigate the relationship between WTC exposure and accelerated aging. After adjustment for race/ethnicity, smoking status, Body Mass Index (BMI), batch and cell type composition, WTC exposure was associated with epigenetic aging acceleration using the Hannum epigenetic clock (β: 3.789; p-value: <0.001). WTC exposure was also associated with epigenetic aging acceleration when using other epigenetic clock types (Horvath and PhenoAge, but not GrimAge), and when stratifying by breast cancer case (β: 3.473; p-value: <0.001) or cancer-free participant (β: 4.369; p-value: 0.001) status. Among all participants, having a breast cancer diagnosis was statistically significantly associated with accelerated aging (β: 1.658; p-value: 0.021). WTC exposure is statistically significantly associated with epigenetic aging acceleration. This was true even after stratifying on cancer status. WTC exposure was positively associated with epigenetic aging acceleration in the overall cohort, among only those women who were cancer-free, and among breast cancer cases. WTC Exposed vs. Unexposed WTC Exposed vs. Unexposed WTC Exposed vs. Unexposed Cancer vs. cancer-free
Key numbers
3.789 years
Increase in Biological Age (Hannum Clock)
Comparison of WTC-exposed vs. unexposed women using the Hannum .
1.658 years
Increase in Biological Age (Breast Cancer Diagnosis)
Association of breast cancer diagnosis with biological age acceleration.
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