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Abstract
Analysis of 1640 methylomes from 894 dogs reveals that epigenetic aging is fastest early in life.
- Epigenetic clocks can predict mortality based on biological aging rates in dogs.
- Larger and male dogs, which tend to have shorter lifespans, show accelerated molecular aging.
- Age-associated changes in DNA methylation were noted at genes related to immune function, indicating conserved biological processes.
- Sex-related methylation changes were primarily found on the X chromosome.
- Size-related DNA methylation alterations were particularly marked at transposable elements, suggesting their role in lifespan differences.
Simplified
Longevity & Aging