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Abstract
People living with HIV may experience age-related health issues earlier than their HIV-negative peers.
- Many individuals with HIV develop cardiovascular, metabolic, neurocognitive, musculoskeletal, and frailty-related conditions more frequently than HIV-negative individuals of the same age.
- DNA methylation-based epigenetic clocks can estimate biological age, potentially clarifying the reasons for increased age-related diseases in people living with HIV.
- There is a need to explore how antiretroviral therapy and sex-related factors may influence epigenetic age acceleration.
- The review summarizes current evidence and biological mechanisms that may contribute to accelerated aging in individuals with HIV.
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