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Epigenetic Clocks in Skin Aging: From Exposome Drivers to Biomarkers and Therapeutic Interventions
Epigenetic Clocks in Skin Aging: Environmental Causes, Biological Markers, and Possible Treatments
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Abstract
Recent advances in epigenetics highlight how environmental factors may accelerate skin aging through specific biological processes.
- Changes in DNA methylation, histone modifications, and non-coding RNAs are linked to the regulation of skin aging.
- Ultraviolet radiation, pollution, smoking, diet, and stress are associated with accelerated skin aging via epigenetic mechanisms.
- The may serve as a tool to quantify biological age and detect premature aging.
- Skin-specific epigenetic clocks could guide therapeutic interventions aimed at reversing or delaying visible signs of aging.
- Epigenetic-targeted therapies, including topical agents and energy-based devices, are being explored for their potential in dermatology.
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Key numbers
78%
Reduction in wrinkle volume
Observed after dihydromyricetin treatment in a small clinical study.
2 years
Epigenetic age reduction
Noted with dihydromyricetin treatment in keratinocytes.