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Epigenetic drift underlies epigenetic clock signals, but displays distinct responses to lifespan interventions, development, and cellular dedifferentiation
Age-related changes in gene regulation explain biological clock signals but respond differently to lifespan treatments, growth, and cell identity loss
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Abstract
Epigenetic clock loci are enriched in regions that both accumulate and lose disorder with age.
- Changes in DNA methylation with age are observed across various species.
- A computational approach was developed to analyze variability or 'disorder' in DNA methylation patterns.
- Age-associated changes in DNA methylation disorder may contribute to the signals used in epigenetic clocks.
- Epigenetic clocks based on regional disorder were created and compared to traditional epigenetic clocks.
- Common responses and key differences were identified between standard epigenetic clocks and those based on disorder.
- These findings suggest a complex relationship between DNA methylation disorder and the processes of epigenetic aging.
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