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Epigenetic H3K4me3 activation of miR-155-5p promotes intervertebral disc degeneration via autophagy and ageing in nucleus pulposus cells
Activation of miR-155-5p by epigenetic changes may promote disc degeneration through cell recycling and aging in spinal disc cells
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Abstract
Knockdown of methyltransferase MLL3 reduces H3K4me3 methylation at the miR-155-5p promoter, affecting intervertebral disc degeneration.
- H3K4me3-associated miRNA pathways are involved in the regulation of transcription factor EB (TFEB) and intervertebral disc degeneration (IVDD).
- MLL3 knockdown leads to decreased transcription of miR-155-5p, which is linked to impaired TFEB activity.
- MiR-155-5p targets FBXO22, which in turn influences TFEB transcription and contributes to nucleus pulposus cell ageing and IVDD.
- MLL3 specifically binds to the miR-155-5p promoter, with no observed interaction at the TFEB or FBXO22 promoters.
- A linear pathway involving H3K4me3, miR-155-5p, FBXO22, and TFEB is identified in the context of IVDD pathogenesis.
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