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The epigenetic rejuvenation promise: Partial reprogramming as a therapeutic strategy for aging and disease
Using partial cell reprogramming to reverse aging and treat disease
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Abstract
Partial reprogramming may help reset epigenetic age and reduce tumorigenic risks associated with full pluripotency.
- Links partial reprogramming to measurable rejuvenation outcomes.
- Defines mesenchymal drift as a reversible pathway related to aging and disease.
- Explores alternatives to the OSKM factors, including small molecules and CRISPR techniques.
- Surveys similar characteristics in various biological systems, focusing on enhanced tissue repair and regeneration.
- Proposes a checklist for preclinical studies, highlighting the importance of schedule, delivery, and safety to facilitate early clinical applications.
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