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Epigenetic remodeling induced by fatty acids: chromatin modifications and cellular senescence during lipid overload
Fatty acids may change gene control and cause cell aging during fat overload
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Abstract
Lipid overload may induce cellular senescence across various cell types and tissues.
- Cellular senescence is a stable state influenced by specific gene expression programs.
- The nature of the stimulus that induces senescence significantly affects these gene expression programs.
- Metabolic stress from lipid overload is particularly relevant in obesity and high-fat diets.
- Fluctuations in key metabolites like acetyl-CoA, NAD⁺, and α-ketoglutarate are linked to changes in chromatin-modifying enzymes.
- Fatty acid-driven metabolic changes may reshape chromatin dynamics, promoting and stabilizing senescence.
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