Journal of translational medicine

3D Genome Structure Biomarkers Reveal Common Biology in ME/CFS, Long COVID, PTSD, Rheumatoid Arthritis, and Multiple Sclerosis

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Abstract

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), Long COVID (LC19), post-traumatic stress disorder (PTSD), rheumatoid arthritis (RA), and multiple sclerosis (MS) share substantial symptom overlap.

  • These disorders are characterized by persistent fatigue, cognitive impairment, autonomic dysfunction, and immune dysregulation.
  • Despite differing diagnoses and clinical presentations, the biological mechanisms underlying these conditions are not well understood.
  • There may be shared regulatory pathways among these disorders that contribute to their symptom similarities.

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