IVW analysis indicates a significant protective effect of on myocardial infarction complications (P = 0.018).
A significant protective association was observed between estrogen receptor-positive breast cancer and acute myocardial infarction (P = 0.007).
analysis suggests that the relationship between estrogen receptor-positive breast cancer and myocardial infarction complications is not confounded by other factors.
MR-Egger analysis indicates potential pleiotropy in the relationship between estrogen receptor-positive breast cancer and acute myocardial infarction.
Sensitivity analysis confirmed the stability of the findings regarding myocardial infarction complications.
Simplified
BACKGROUND: (ER + BC) is the most prevalent subtype of breast cancer. However, the causal relationship between ER + BC and myocardial infarction complications remains unclear. While observational studies suggest a potential association between ER + BC and cardiovascular events, existing evidence does not provide sufficient causal inference. (MR) serves as a powerful method for investigating the causal links between genetic variables and disease outcomes.
OBJECTIVE: The central goal of this study is to assess the genetic basis for the associations between ER + BC and complications of myocardial infarction (MI Complications), as well as between ER + BC and acute myocardial infarction (Acute MI), employing MR as the analytical framework.
METHODS: A two-sample MR analysis was conducted, with ER + BC as the exposure variable and Acute MI and MI Complications as outcomes.The exposure and outcome data in this study were both downloaded from publicly available databases on MR-Base, a resource provided by the MRC Integrative Epidemiology Unit.Causal inference was performed using inverse variance weighting (IVW), MR-Egger, weighted median, simple mode, and weighted mode methods. Heterogeneity was assessed with Cochrane's Q test, and pleiotropy was evaluated using the MR-Egger intercept test and MR-PRESSO, to provide additional assurance regarding the robustness of the findings.
RESULTS: IVW analysis revealed a significant protective effect of ER + BC on MI Complications (P = 0.018), with a P-value of 0.007 for the effect on Acute MI. However, MR-Egger suggests that the relationship between ER + BC and Acute MI exhibits pleiotropy.Additionally, the MR analysis found no evidence of pleiotropy (P > 0.05) or heterogeneity (P > 0.05) between ER + BC and MI Complication, suggesting that the causal relationship is not confounded by other potential factors. Furthermore, the leave-one-out sensitivity analysis confirmed the stability of the findings.
CONCLUSION: This study provides genetic evidence supporting a protective relationship of causality between ER + BC and Acute MI, as well as MI Complications. The MR analysis suggests that ER + BC may reduce the risk of MI Complications. These findings offer new perspectives for clinical interventions and public health policies.
Key numbers
0.018
Protective Effect on MI Complications
P-value indicating the significance of the protective effect of ER + BC on MI complications.
0.007
P-value for Acute MI
P-value showing the significance of the association between ER + BC and acute myocardial infarction.
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Declarations. Consent for publication: Not applicable. Ethics Declaration for Public Databases:: Ethics declaration: As this study used publicly available GWAS data, the study protocol and details were not pre-registered. All data used from public databases have been obtained with appropriate ethical approval and comply with relevant ethical standards and privacy protection requirements.The study adheres to the ethical guidelines for data use and ensures compliance with applicable laws and regulations in the access and handling of the data. Competing interests: The authors declare no competing interests.
