IVW analysis indicates a significant protective effect of on myocardial infarction complications (P = 0.018).
A significant protective association was observed between estrogen receptor-positive breast cancer and acute myocardial infarction (P = 0.007).
analysis suggests that the relationship between estrogen receptor-positive breast cancer and myocardial infarction complications is not confounded by other factors.
MR-Egger analysis indicates potential pleiotropy in the relationship between estrogen receptor-positive breast cancer and acute myocardial infarction.
Sensitivity analysis confirmed the stability of the findings regarding myocardial infarction complications.
Simplified
BACKGROUND: (ER + BC) is the most prevalent subtype of breast cancer. However, the causal relationship between ER + BC and myocardial infarction complications remains unclear. While observational studies suggest a potential association between ER + BC and cardiovascular events, existing evidence does not provide sufficient causal inference. (MR) serves as a powerful method for investigating the causal links between genetic variables and disease outcomes.
OBJECTIVE: The central goal of this study is to assess the genetic basis for the associations between ER + BC and complications of myocardial infarction (MI Complications), as well as between ER + BC and acute myocardial infarction (Acute MI), employing MR as the analytical framework.
METHODS: A two-sample MR analysis was conducted, with ER + BC as the exposure variable and Acute MI and MI Complications as outcomes.The exposure and outcome data in this study were both downloaded from publicly available databases on MR-Base, a resource provided by the MRC Integrative Epidemiology Unit.Causal inference was performed using inverse variance weighting (IVW), MR-Egger, weighted median, simple mode, and weighted mode methods. Heterogeneity was assessed with Cochrane's Q test, and pleiotropy was evaluated using the MR-Egger intercept test and MR-PRESSO, to provide additional assurance regarding the robustness of the findings.
RESULTS: IVW analysis revealed a significant protective effect of ER + BC on MI Complications (P = 0.018), with a P-value of 0.007 for the effect on Acute MI. However, MR-Egger suggests that the relationship between ER + BC and Acute MI exhibits pleiotropy.Additionally, the MR analysis found no evidence of pleiotropy (P > 0.05) or heterogeneity (P > 0.05) between ER + BC and MI Complication, suggesting that the causal relationship is not confounded by other potential factors. Furthermore, the leave-one-out sensitivity analysis confirmed the stability of the findings.
CONCLUSION: This study provides genetic evidence supporting a protective relationship of causality between ER + BC and Acute MI, as well as MI Complications. The MR analysis suggests that ER + BC may reduce the risk of MI Complications. These findings offer new perspectives for clinical interventions and public health policies.
Key numbers
0.018
Protective Effect on MI Complications
P-value indicating the significance of the protective effect of ER + BC on MI complications.
0.007
P-value for Acute MI
P-value showing the significance of the association between ER + BC and acute myocardial infarction.
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