Subjective and objective subtypes of excessive daytime sleepiness in Parkinson's disease

Dec 12, 2019Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

Different types of excessive daytime sleepiness in Parkinson's disease based on personal experience and measurements

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Abstract

Excessive daytime sleepiness (DS) is reported by 68.6% of patients with Parkinson's disease (PD).

Subjective excessive daytime sleepiness is identified as a significant non-motor symptom of Parkinson's disease.
A disassociation between subjective and objective excessive daytime sleepiness occurs in 32.5% of patients.
Dopaminergic medication use is associated with the development of excessive daytime sleepiness.
Affective disorders, such as anxiety and depression, may contribute to subjective excessive daytime sleepiness.

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BACKGROUND: Excessive daytime sleepiness (DS) is a common symptom of Parkinson's disease (PD), which can occur at any stage of the disease and decrease the quality of life of patients. The relationship between excessive daytime sleepiness and Parkinson's disease is determined by neurodegenerative process in the brain structures. However, there are many other factors, which can contribute to this phenomenon.

AIM: To assess the prevalence and causes of DS as well as its impact on the quality of life of patients.

MATERIAL AND METHODS: Seventy patients (mean age 65.0±8.4 years) with PD, stage I-III, including 48 patients with DS and 22 without DS, were examined. All patients underwent clinical/neurological and neuropsychological examinations using a set of scales and polysomnography, if necessary.

RESULTS AND CONCLUSION: Sleep disorders are the most frequent non-motor symptoms of PD. The prevalence of subjective DS is determined for the first time. The disassociation between subjective and objective DS is observed in 32,5% of patients. Clinical combinations of DS with other sleep disorders are described. Taking dopaminergic medication contributes significantly to the development of DS and affective disorders (anxiety, depression) play a role in subjective DS.

Subjective and objective subtypes of excessive daytime sleepiness in Parkinson's disease

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