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Once‐Weekly Exenatide: An Extended‐Duration Glucagon‐Like Peptide Agonist for the Treatment of Type 2 Diabetes Mellitus
Once-weekly exenatide as a long-lasting treatment for type 2 diabetes
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Abstract
Once-weekly exenatide is a 2-mg injection that may improve hemoglobin A1c levels and result in weight loss.
- Exenatide is an extended-duration glucagon-like peptide-1 (GLP-1) agonist administered once every 7 days.
- It has pharmacotherapeutic effects that are superior to twice-daily exenatide and sitagliptin, and comparable to insulin glargine.
- Adverse effects include gastrointestinal issues, hypoglycemia, injection-site reactions, pancreatitis, and antibody development.
- Patients with a personal or family history of thyroid tumors should not use once-weekly exenatide.
- Monitoring is necessary to prevent delays in gastric absorption when taken with orally administered drugs.
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