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Abstract
Essence
Swimming exercise may ease cognitive impairment in Alzheimer's disease mice through skeletal muscle extracellular vesicles that help microglia clear amyloid-beta plaques.
Evidence
This mouse and cell-model experiment used gain- and loss-of-function tests to trace exercise-induced skeletal muscle-derived extracellular vesicles, miR-378a-3p cargo, microglial uptake, plaque clearance, and cognition in AD mice.
Caveat
The therapeutic claim is limited to preclinical AD models and engineered myotube-derived vesicles, not tested human Alzheimer's disease treatment.
Simplified
Longevity & Aging