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Abstract
Alzheimer's disease may be influenced by the gut microbiota, with exercise playing a significant role in modulating its diversity.
- The gut microbiota is linked to the regulation of the central nervous system, impacting behavior and cognitive functions in Alzheimer's disease.
- Physical exercise may slow Alzheimer's disease progression by positively affecting the gut microbiota's composition and diversity.
- Exercise could enhance cognitive function by altering the synthesis and metabolism of neuroactive substances like glutamate and aspartate.
- Modulation of gut microbiota through exercise may reduce neuroinflammation, amyloid-β deposition, and tau phosphorylation.
- Exercise is associated with the regulation of metabolites such as short-chain fatty acids, which help maintain blood-brain barrier integrity.
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