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Exercise-induced irisin rescues lead-induced cognitive impairment by inhibiting prefrontal cortical senescence via SIRT3
Exercise-related irisin may improve lead-caused thinking problems by slowing aging in the brain's decision-making area through SIRT3
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Abstract
Exercise and exercise serum may mitigate lead-induced cognitive impairment by influencing the irisin-SIRT3 pathway.
- Lead exposure is linked to cognitive impairment through senescence in the prefrontal cortex.
- Exercise in mice reduced lead-induced senescence and improved cognitive function.
- Irisin, derived from exercise, appears to alleviate cellular senescence by regulating the SIRT3 signaling pathway.
- In humans, irisin may mediate the relationship between blood lead levels and cognitive scores.
- These findings indicate that targeting irisin could offer a new approach to address lead-induced cognitive decline.
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