Translational neurodegeneration

Exercise may reduce brain immune cell activity to boost fat breakdown and improve thinking in Alzheimer's disease

Updated

Abstract

Autophagy-lysosomal dysfunction is associated with lipid droplet accumulation in Alzheimer's disease.

  • Lipid droplet accumulation may drive the pathological progression of Alzheimer's disease.
  • Exercise has been reported to restore autophagy-lysosomal function in Alzheimer's disease.
  • The impact of exercise on lipid droplet deposition in Alzheimer's disease is currently unknown.

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