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Abstract
Mitochondrial dysfunction in aging muscle is linked to symptoms such as limited mobility, fatigue, and weakness.
- Impaired mitochondrial dynamics, including key processes like mitophagy, fusion, and fission, contribute to muscle aging.
- Exercise may enhance mitochondrial health by improving the processes of biogenesis, dynamics, and turnover.
- Molecular mechanisms activated by exercise can support mitochondrial function and promote muscle cell balance.
- Key pathways such as AMPK, PGC-1α, and SIRT1 are involved in how exercise influences mitochondrial adaptations.
- Exercise is associated with improved mitochondrial quality control and muscle function, offering potential as a non-drug intervention for mitochondrial diseases.
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