Exercise training alters circadian clock dynamics in cancer-bearing male mice.

Scheduled exercise at ZT2 significantly increased the amplitude of core clock gene expression rhythms in tumor tissue.

• Alterations in circadian timing mechanisms may contribute to tumor initiation and progression.
• Malignant cells can disrupt the expression and synchronization of core clock genes.
• Physical exercise is a known modulator of circadian rhythms in peripheral tissues.
• In a mouse model of lung cancer, exercise at a fixed time (ZT2) enhanced the rhythmicity of Per2, Per3, and Rev-Erbα genes.
• No rhythmic enhancement was observed when exercise was performed at alternating times (ZTAlt).
• The timing of exercise may influence the immune response, as indicated by a shift in TNF-α acrophase in the ZT2 group.

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