Exercise reduces fat tissue inflammation in obese mice by lowering immune cell buildup and changing immune cell types

Exercise training significantly increased CD163 mRNA expression, a marker of M2 macrophages, in adipose tissue of high-fat diet-induced obese mice.

• Mice on a high-fat diet showed increased mRNA expression of CD11c, a marker for M1 macrophages, which was reduced with exercise training.
• Exercise training significantly inhibited TNF-alpha and F4/80 mRNA expression, indicating a reduction in pro-inflammatory signals in adipose tissue.
• The increase in ICAM-1 mRNA expression due to a high-fat diet was attenuated by exercise training.
• Exercise training did not result in weight loss or reduction of adipose tissue mass in high-fat diet mice.
• Higher mRNA expression of TLR4, associated with pro-inflammatory cytokine production, was strongly inhibited by exercise training.

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