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Exogenous estrogen enhances T cell activation in male primates
External estrogen increases immune cell activation in male primates
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Abstract
E2 treatment resulted in significantly higher frequencies of CCR5CD4T cells in male rhesus macaques compared to placebo.
- Estrogen treatment suppressed endogenous testosterone production and induced female physical traits in male rhesus macaques.
- Blood cell counts and chemistry profiles were altered following 7 months of 17β-estradiol therapy.
- E2 treatment attenuated innate immune responses while increasing T cell activation.
- After mRNA vaccination, E2-treated macaques had greater frequencies of CCR5CD4T cells, which are key targets for HIV-1 replication.
- The findings suggest the need for further investigation into how elevated estrogen levels may influence HIV susceptibility.
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