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Extracellular biogenic nanoscale mitochondria reprogram the wound microenvironment via ROS scavenging independent of cellular uptake
Tiny mitochondria outside cells change the wound environment by removing harmful molecules without entering cells
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Abstract
Topically applied mesenchymal stem cell-derived mitochondria (MSC-mt) significantly accelerate wound closure in a murine skin injury model.
- Chronic non-healing ulcers in pediatric patients exhibit metabolic insufficiency and hindered regenerative signaling.
- MSC-mt enhance angiogenesis, collagen deposition, and fibroblast survival while reducing oxidative stress and apoptosis.
- The cytoprotective effects of MSC-mt primarily occur through the removal of reactive oxygen species (ROS) outside of cells.
- Excessive immobilization of MSC-mt within a thermosensitive hydrogel limits their effectiveness.
- Under conditions of high oxidative stress, internalized MSC-mt trigger a cellular quality-control response involving mitophagy.
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