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Abstract
Extracellular vesicle-lipid hybrid systems may enhance RNA delivery for cancer therapy.
- RNA therapeutics face challenges such as rapid degradation and inefficient cellular uptake.
- Extracellular vesicles are recognized for their high biocompatibility and potential as drug delivery vehicles.
- Liposomes and lipid nanoparticles allow for customizable lipid composition and effective loading of nucleic acids.
- Combining extracellular vesicles with lipid carriers has led to hybrid systems that leverage their complementary properties.
- The review categorizes hybrid systems based on structural architecture and RNA-loading strategies.
- Safety evaluation challenges and future directions for clinical application are also addressed.
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