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Farnesoid X Receptor-Mediated Bile Acids Regulation in Cholestasis
How the Farnesoid X Receptor Controls Bile Acid Levels in Bile Flow Blockage
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Abstract
The farnesoid X receptor (FXR) is essential for regulating bile acid metabolism and has binding locations near previously undisclosed target genes.
- FXR plays a crucial role in the metabolism of bile acids, glucose, and lipids.
- It is primarily located in the liver and intestines, with lesser amounts in the kidneys and heart.
- FXR influences various cellular activities, including inflammation and apoptosis, through its interaction with transcriptional regulators.
- The receptor helps maintain bile acid balance by stimulating the expression of specific proteins that inhibit bile acid synthesis.
- The study explores FXR's involvement in bile acid metabolism and its potential connection to cholestasis-related disorders.
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