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Farnesoid X receptor deficiency accelerates aging and systemic functional decline in male mice
Lack of a key liver receptor speeds up aging and body decline in male mice
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Abstract
FXR knockout mice have significantly shorter lifespan and healthspan than wild-type mice.
- Loss of FXR is associated with increased neurodegeneration and impaired motor function.
- Multi-organ deterioration and metabolic imbalance are observed in FXR-deficient mice.
- Transcriptomic profiling indicates dysregulation of aging-related pathways due to FXR deficiency.
- Key signaling pathways, such as p53 and PI3K-Akt, are suppressed in the absence of FXR.
- Aberrant activation of bile acid and lipid metabolism occurs with FXR knockout.
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