Frontiers in immunology

Increased fat-making activity in aging immune cells may contribute to worsening liver scarring

Updated

Abstract

Macrophages are key regulators in the development of liver fibrosis.

  • Liver fibrosis is a significant pathological stage associated with chronic liver diseases.
  • Macrophages play crucial roles in the body's innate immune response.
  • Cellular senescence refers to a state where cells irreversibly stop dividing.
  • The role of senescent macrophages in liver fibrosis is not fully understood.

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