The synergistic regulation of fat reduction mechanism by tea polyphenols through the gut-microbial-brain axis and gut-liver axis

Feb 20, 2026International journal of food sciences and nutrition

How Tea Compounds May Help Reduce Fat by Working Together Through Gut-Brain and Gut-Liver Systems

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Abstract

Tea polyphenols may reshape gut microbiota and influence energy balance.

  • Obesity is associated with intestinal dysbiosis, metabolic disorders, and neuroendocrine signals.
  • Tea polyphenols could mediate interactions between the gut-brain and gut-liver axes.
  • Modulation of gut microbiota metabolites, such as short-chain fatty acids and secondary bile acids, is observed.
  • These metabolites may inhibit central appetite while promoting fatty acid oxidation through liver pathways.
  • The findings suggest a multi-dimensional network for fat reduction involving tea polyphenols.

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