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Feeding entrainment of the primary and accessory loops of the molecular circadian clock and epigenetic processes in zebrafish brain: the importance of the glucocorticoid signalling
How Feeding Times Affect the Main and Backup Body Clocks and Gene Regulation in Zebrafish Brain, Highlighting the Role of Stress Hormone Signals
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Abstract
Clock genes in zebrafish brain exhibit varied responses to feeding time and glucocorticoid receptor absence.
- The primary loop clock genes (bmal1a, per1b) maintained their rhythmic patterns regardless of feeding time or genotype.
- In contrast, secondary loop genes (rev-erbα, rorα) were influenced by both the absence of glucocorticoid receptors and feeding schedules.
- Bdnf expression was primarily affected by feeding time, indicating its regulation by the circadian system.
- Pparα levels linked to metabolism were altered by both feeding time and the absence of glucocorticoid receptors.
- Loss of glucocorticoid receptors had a stronger impact on epigenetic genes during the day compared to night.
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