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How Meal Timing and Diet Together Affect Liver Fat and Gene Activity in Male Rats
Updated
Abstract
Animals with access to a free-choice high-fat, high-sugar diet only during the light period showed more hepatic fat accumulation than those fed during the dark period despite consuming fewer calories.
- Feeding a high-fat, high-sugar diet in the light period is associated with increased fat storage in the liver.
- Chow-fed animals that ate during the light period had the lowest liver fat content and caloric intake.
- Patterns of movement and heat production corresponded with feeding times, except for those on the high-fat diet fed in the light.
- The timing of food intake influenced the daily rhythms of liver clock and metabolic gene expression.
- In the high-fat diet light-fed group, clock gene expression was advanced by 3 hours compared to the chow light-fed group.
Simplified
Key numbers
fcHFHS light-fed vs. fcHFHS dark-fed
Increase in hepatic fat accumulation
Hepatic fat accumulation was significantly higher in light-fed fcHFHS animals.
3 hours
3-hour advance in clock gene expression
Clock gene expression was advanced in fcHFHS light-fed rats compared to chow light-fed rats.