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Synergistic Effect of Feeding Time and Diet on Hepatic Steatosis and Gene Expression in Male Wistar Rats
How Meal Timing and Diet Together Affect Liver Fat and Gene Activity in Male Rats
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Abstract
Animals with access to a free-choice high-fat, high-sugar diet only during the light period showed more hepatic fat accumulation than those fed during the dark period despite consuming fewer calories.
- Feeding a high-fat, high-sugar diet in the light period is associated with increased fat storage in the liver.
- Chow-fed animals that ate during the light period had the lowest liver fat content and caloric intake.
- Patterns of movement and heat production corresponded with feeding times, except for those on the high-fat diet fed in the light.
- The timing of food intake influenced the daily rhythms of liver clock and metabolic gene expression.
- In the high-fat diet light-fed group, clock gene expression was advanced by 3 hours compared to the chow light-fed group.
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Key numbers
fcHFHS light-fed vs. fcHFHS dark-fed
Increase in hepatic fat accumulation
Hepatic fat accumulation was significantly higher in light-fed fcHFHS animals.
3 hours
3-hour advance in clock gene expression
Clock gene expression was advanced in fcHFHS light-fed rats compared to chow light-fed rats.