Regulation of Ferroptosis in Cancer and Immune Cells

Mar 13, 2025Immune network

Control of Iron-Related Cell Death in Cancer and Immune Cells

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Regenerative Health on OpenScience ↗PubMed ↗DOI ↗OA ↗

Abstract

is an iron-dependent form of regulated cell death influenced by lipid peroxidation.

Ferroptosis varies in susceptibility among immune cell types, lipid compositions, and metabolic needs.
The process may impact immune responses in contexts such as cancer, infections, and autoimmune diseases.
Targeting ferroptosis could enhance antitumor immunity or inhibit immunosuppressive cells in cancer therapy.
The review discusses metabolic pathways that regulate ferroptosis and its dual roles in tumor progression and immunity.
Therapeutic implications of ferroptosis are context-dependent and could optimize cancer treatment strategies.

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, an iron-dependent form of regulated cell death, is driven by lipid peroxidation and shaped by metabolic and antioxidant pathways. In immune cells, ferroptosis susceptibility varies by cell types, lipid composition, and metabolic demands, influencing immune responses in cancer, infections, and autoimmune diseases. Therapeutically, targeting ferroptosis holds promise in cancer immunotherapy by enhancing antitumor immunity or inhibiting immunosuppressive cells. This review highlights the metabolic pathways underlying ferroptosis, its regulation in immune cells, its dual role in tumor progression and antitumor immunity, and its context-dependent therapeutic implications for optimizing cancer treatment.

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Regulation of Ferroptosis in Cancer and Immune Cells

Abstract

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