research in lung cancer has shifted focus towards clinical applications, particularly targeting GPX4.
The analysis highlights a transition from basic mechanisms to clinical applications in ferroptosis research.
Key areas of interest include the development of GPX4-targeted therapies and combination treatments.
Increased international collaboration has positioned the United States and China as leading contributors.
Interdisciplinary studies have provided new insights into the interaction between ferroptosis, the tumor microenvironment, and the immune system.
Ferroptosis may help overcome drug resistance by regulating iron-dependent lipid peroxidation.
Future research is suggested to focus on translating ferroptosis-based therapies into personalized medicine for lung cancer.
Simplified
BACKGROUND: Lung cancer remains the leading cause of cancer-related deaths worldwide, with increasing attention being given to novel therapeutic strategies that target the mechanisms underlying tumor growth and drug resistance. Among these, , a regulated cell death driven by iron-dependent lipid peroxidation, has become a key focus in cancer research. Despite extensive research, the exact role of ferroptosis in lung cancer progression and treatment remains unclear, especially regarding its interaction with immune cells and the tumor microenvironment.
OBJECTIVE AND METHODS: To address these limitations, this study utilizes a comprehensive bibliometric analysis to explore the current landscape of ferroptosis research in lung cancer. We collected data from the Web of Science Core Collection, covering articles published between 2015 and 2025, and analyzed them using advanced tools such as VOSviewer and CiteSpace.
RESULTS: This study uses a comprehensive bibliometric analysis to uncover key trends and emerging areas related to lung cancer in ferroptosis research. Recently, the focus has shifted from basic mechanisms to clinical applications, particularly in developing GPX4-targeted therapies and combination treatments. With increasing international collaboration, the United States and China have become key players. Interdisciplinary research, especially on ferroptosis and the cancer-immune system, offers new insights into its role in the tumor microenvironment and immunotherapy. Ferroptosis shows excellent promise in overcoming drug resistance by regulating iron-dependent lipid peroxidation and enhancing treatment efficacy. Future research should focus on ferroptosis' clinical translation, particularly in personalized medicine and overcoming resistance, offering broad prospects for lung cancer treatment.
CONCLUSION: This paper provides valuable insights into the trends, key contributors, and emerging frontiers of ferroptosis research in lung cancer. It identifies important developments that can serve as a foundation for translating ferroptosis-based therapies into clinical practice, particularly to address drug resistance in lung cancer.
Key numbers
1664
Total Articles
Total articles retrieved for analysis on and lung cancer.
3
Leading Countries
Top countries maintaining high research cooperation in studies.
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Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.
