Development and psychopathology

Flatter daily cortisol patterns linked to depression and anxiety in late teens: the role of stress and daily negative feelings

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Abstract

In a sample of 300 adolescents, those with a history of major depression disorder (MDD) exhibited flatter diurnal cortisol slopes than peers without internalizing disorders.

  • Adolescents with past MDD and recent MDD comorbid with anxiety disorders showed reduced cortisol variation throughout the day.
  • Increased general distress was linked to flatter cortisol slopes, suggesting a potential relationship between emotional state and HPA axis functioning.
  • Feelings of sadness and loneliness correlated with flatter cortisol slopes and contributed to the link between comorbid MDD and anxiety disorders.
  • Past experiences of MDD may leave a lasting impact on cortisol slopes, independent of current negative emotions or life stress.

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