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The Therapeutic Potential of Flavonols in Alzheimer's Disease: Inhibiting Amyloid‐β, Oxidative Stress, and Neuroinflammation
Flavonols may help treat Alzheimer's by reducing harmful protein buildup, cell damage, and brain inflammation
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Abstract
Flavonols are shown to effectively inhibit Aβ oligomerization and fibril formation, addressing key aspects of Alzheimer's disease pathology.
- Flavonols activate the Nrf2/HO-1 pathway, reducing oxidative stress associated with Alzheimer's disease.
- They modulate microglial polarization, which is linked to suppression of neuroinflammation.
- Quercetin enhances synaptic plasticity and reduces tau phosphorylation through activation of TrkB signaling.
- Kaempferol prevents Aβ-induced cell death and improves cognitive outcomes by inhibiting acetylcholinesterase activity.
- Myricetin improves mitochondrial function and reduces oxidative damage via GSK3β/ERK2 signaling.
- Fisetin upregulates neprilysin expression, which is associated with reduced Aβ burden and improved synaptic function.
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