Fluorinated Lipid Nanoparticles for Enhancing mRNA Delivery Efficiency

Fluorinated modification of lipid nanoparticles can enhance mRNA expression efficiency nearly 2-fold in primary dendritic cells.

• Fluorinated lipid modification accounts for only 1.5% of the lipids in the nanoparticles.
• This modification can mediate a 5-fold enhancement of mRNA expression efficiency in tumor cells.
• Mechanistic studies indicate that fluorinated lipids promote cellular uptake of nanoparticles and help them escape endosomes.
• Overall mRNA expression is augmented at least 3-fold with fluorinated nanoparticles compared to nonfluorinated counterparts at low doses.
• Fluorinated lipid nanoparticles demonstrate favorable biosafety profiles in both cellular and animal models.

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