Fluorine in the pharmaceutical industry: Synthetic approaches and application of clinically approved fluorine-enriched anti-infectious medications

Apr 28, 2024European journal of medicinal chemistry

Fluorine in medicine: How it is made and used in approved anti-infection drugs

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Abstract

Fluorine atoms significantly influence the efficacy of anti-infectious agents.

The incorporation of fluorine into anti-infectious drugs enhances their chemical and biological properties.
Clinically approved medications demonstrate improved efficacy due to fluorination.
Specific molecular mechanisms associated with fluorination contribute to the effectiveness of these therapies.
The review provides a comprehensive analysis of current fluorine-enriched drugs and their development.
Insights from this analysis may guide future drug design for next-generation anti-infectious agents.

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The strategic integration of fluorine atoms into anti-infectious agents has become a cornerstone in the field of medicinal chemistry, owing to the unique influence of fluorine on the chemical and biological properties of pharmaceuticals. This review examines the synthetic methodologies that enable the incorporation of fluorine into anti-infectious drugs, and the resultant clinical applications of these fluorine-enriched compounds. With a focus on clinically approved medications, the discussion extends to the molecular mechanisms. It further outlines the specific effects of fluorination, which contribute to the heightened efficacy of anti-infective therapies. By presenting a comprehensive analysis of current drugs and their developmental pathways, this review underscores the continuing evolution and significance of fluorine in advancing anti-infectious treatment options. The insights offered extend valuable guidance for future drug design and the development of next-generation anti-infectious agents.

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Fluorine in the pharmaceutical industry: Synthetic approaches and application of clinically approved fluorine-enriched anti-infectious medications

Abstract

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