Forced degradation and impurity profiling: Recent trends in analytical perspectives

Aug 24, 2013Journal of pharmaceutical and biomedical analysis

Recent Advances in Testing Drug Breakdown and Impurities

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Abstract

This review highlights trends in the analysis of degradation and impurities in pharmaceuticals from 2008 to 2012.

Analytical perspectives include forced degradation and impurity profiling of active pharmaceutical ingredients and drug products.
Various analytical methods, including hyphenated techniques, are discussed for identifying and quantifying impurities.
The review categorizes findings based on year of publication, type of chromatography, and therapeutic categories of drugs.
Different pharmaceutical matrices, including APIs and dosage forms, are analyzed for their degradation profiles.

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This review describes an epigrammatic impression of the recent trends in analytical perspectives of degradation and impurities profiling of pharmaceuticals including active pharmaceutical ingredient (API) as well as drug products during 2008-2012. These recent trends in forced degradation and impurity profiling were discussed on the head of year of publication; columns, matrix (API and dosage forms) and type of elution in chromatography (isocratic and gradient); therapeutic categories of the drug which were used for analysis. It focuses distinctly on comprehensive update of various analytical methods including hyphenated techniques for the identification and quantification of thresholds of impurities and degradants in different pharmaceutical matrices.

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Forced degradation and impurity profiling: Recent trends in analytical perspectives

Abstract

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