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Abstract
Aging is associated with profound alterations in the chromatin landscape.
- Chromatin changes during aging lead to widespread modifications in gene expression and cellular functions.
- FOXO proteins are recognized as key regulators of chromatin that integrate metabolic signals with epigenetic changes.
- Evidence suggests that FOXO proteins may exhibit pioneer activity that facilitates their engagement with chromatin.
- FOXO proteins could regulate chromatin dynamics through ATP-dependent remodeling and modifications of histones.
- These mechanisms are associated with the development of age-related chromatin states and cellular aging.
- Current therapeutic strategies targeting FOXO face challenges related to specific isoforms and chromatin contexts.
Simplified
Longevity & Aging