Fragile lifespan expansion by dietary mitohormesis in C. elegans

High dietary glucose activates the mitochondrial unfolded protein response (UPRmt) to protect against lifespan reduction.

• Mitochondrial function is crucial for longevity, and imbalances in mitonuclear protein levels can trigger protective responses.
• Toxic compounds can activate the UPRmt, but sublethal doses may actually extend lifespan in simple organisms like C. elegans.
• Lifelong high glucose consumption decreases lifespan, while restricting glucose exposure to developmental stages can extend lifespan.
• The extension of lifespan from glucose exposure during development requires the activation of the UPRmt.
• Further mitochondrial stress in adult animals negates the lifespan extension benefits of prior UPRmt activation.

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