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From geroscience to precision geromedicine: Understanding and managing aging
Understanding and managing aging from aging science to personalized medicine
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Abstract
Aging may be promoted by overactivation of gerogenes, which are genes that favor biological aging.
- Gerogenes are associated with age-related diseases in human studies.
- Gerosuppressors can slow down the aging process, similar to how tumor suppressors prevent cancer.
- Interactions between gerogenes, gerosuppressors, and various risk factors contribute to individual differences in aging and disease onset.
- New molecular profiling technologies can identify gerogenic and gerosuppressive pathways as biomarkers of aging.
- Precision geromedicine aims to tailor treatments based on a person's genetic and biomarker profiles, along with psychosocial factors.
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