Cell

Understanding and managing aging from aging science to personalized medicine

Updated

Abstract

Aging may be promoted by overactivation of gerogenes, which are genes that favor biological aging.

  • Gerogenes are associated with age-related diseases in human studies.
  • Gerosuppressors can slow down the aging process, similar to how tumor suppressors prevent cancer.
  • Interactions between gerogenes, gerosuppressors, and various risk factors contribute to individual differences in aging and disease onset.
  • New molecular profiling technologies can identify gerogenic and gerosuppressive pathways as biomarkers of aging.
  • Precision geromedicine aims to tailor treatments based on a person's genetic and biomarker profiles, along with psychosocial factors.

Simplified

Full Text

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Funding

Competing interests

Declaration of interests G.K. holds research contracts with Daiichi Sankyo, Kaleido, Lytix Pharma, PharmaMar, Osasuna Therapeutics, Samsara Therapeutics, Sanofi, Sutro, Tollys, and Vascage; is on the Board of Directors of the Bristol Myers Squibb Foundation France; is a scientific co-founder of everImmune, Osasuna Therapeutics, Samsara Therapeutics, and Therafast Bio; is on the scientific advisory boards of Centenara Labs (formerly Rejuveron Life Sciences), Hevolution, and Institut Servier; and is the inventor of patents covering therapeutic targeting of ACBP/DBI, aging, cancer, cystic fibrosis, and metabolic disorders. G.K.’s wife, Laurence Zitvogel, has held research contracts with Glaxo Smyth Kline, Incyte, Lytix, Kaleido, Innovate Pharma, Daiichi Sankyo, Pilege, Merus, transgene, 9 m, Tusk, and Roche; was on the Board of Directors of Transgene; is a co-founder of everImmune; and holds patents covering the treatment of cancer and the therapeutic manipulation of the microbiota. G.K.’s brother, Romano Kroemer, was an employee of Sanofi and now consults for Boehringer Ingelheim. A.B.M. is co-founder of Chi Longevity, Chief Medical Officer of NU, and holds research or advisory contracts with Abbott, Danone, Haleon, Borealis Pharma, Rejuveron, Institute for Healthier Living Abu Dhabi, Atria Institute, Hevolution, and PwC. A.M.C. is co-founder of Selphagy (a program under LifeBioscience). V.G. is a consultant to Genflow Bio, DoNotAge, Elysium, WndrHLTH, and BellSant and is a co-founder of Matrix Bio and Faunsome Bio. V.N.G. is an inventor of patent applications dealing with aging biomarkers. B.K.K. reports a relationship with Ponce de Leon Health that includes consulting or advisory and equity or stocks. E.V. is a member of the SAB of BioAge, Deciduous, Rejuvenate Biomed, GenFlow, Amazentis, Longevity Clinic Europe, and Institute of Healthy Living Abu Dhabi. F.S. is the founder of Geroscience Consulting LLC. The funders had no role in the design of the study, in the writing of the manuscript, or in the decision to publish the results.
PubMed

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