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From gestational chronodisruption to noncommunicable diseases: Pathophysiological mechanisms of programming of adult diseases, and the potential therapeutic role of melatonin
How Disrupted Day-Night Signals During Pregnancy May Lead to Adult Diseases and How Melatonin Could Help
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Abstract
Gestational chronodisruption may increase the susceptibility to noncommunicable diseases (NCDs) in adult life.
- The developing fetus relies on maternal circadian signals for optimal growth and preparation for life outside the womb.
- Modern factors like light pollution and shift work can disrupt these circadian rhythms.
- Gestational chronodisruption is linked to adverse effects on cardiovascular, neurodevelopmental, metabolic, and endocrine functions in the fetus.
- Such disruptions may have long-term consequences that extend into adulthood.
- Environmental factors like diet and stress can worsen the negative impacts of gestational chronodisruption.
- Melatonin supplementation during pregnancy could be a potential intervention, though further research is needed.
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