FUBL-3/FUBP1 helps change DNA packaging during mitochondrial stress and may influence lifespan

FUBL-3, a protein linked to human FUBP1, is identified as a key regulator of chromatin remodeling in response to mitochondrial stress.

• FUBL-3 translocates to intestinal nuclei during mitochondrial stress, indicating its role in cellular response.
• It drives nucleosome remodeling and chromatin condensation, which are crucial for activating the mitochondrial unfolded protein response.
• Loss of FUBL-3 disrupts chromatin compaction and prevents lifespan extension under stress conditions.
• Overexpression of FUBL-3 restructures chromatin, triggers the unfolded protein response, and extends lifespan.
• Human FUBP1 can rescue chromatin remodeling functions in a worm model, suggesting conservation across species.

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